Alzheimer’s disease may not just be a neurological condition—it could be linked to bacterial infections. New research suggests that Porphyromonas gingivalis, the bacteria behind gum disease, might play a role in the development of this devastating illness.
Key Facts:
- A 2019 study linked *Porphyromonas gingivalis*, the bacteria behind gum disease, to Alzheimer’s disease.
- Researchers found this pathogen in the brains of deceased Alzheimer’s patients.
- Infected mice showed increased amyloid beta production, a key Alzheimer’s marker.
- The study also found bacterial toxins in brains of people without diagnosed dementia.
- A drug, COR388, reduced brain infection and inflammation in animal tests.
The Rest of The Story:
A growing body of research suggests that Alzheimer’s disease may not just be a neurological disorder but also an infection-related condition.
Scientists found P. gingivalis—the bacteria responsible for gum disease—in the brains of Alzheimer’s patients.
This discovery raises important questions about whether gum disease could contribute to the development of Alzheimer’s rather than just being a side effect of cognitive decline.
This week’s paper is from 2019, and the authors find evidence that the bacteria Porphyromonas gingivalis, which is associated with chronic gum diseases, is involved in the pathology of Alzheimer's.
Paper here: https://t.co/QF3a3Pnow0 pic.twitter.com/7cYznSSqzN
— Fermat's Library (@fermatslibrary) February 18, 2020
The study showed that mice orally infected with P. gingivalis developed brain infections and increased amyloid beta levels, a hallmark of Alzheimer’s.
Additionally, toxic enzymes produced by the bacteria were found even in people without a dementia diagnosis, suggesting the infection might precede symptoms.
A potential treatment, COR388, showed promise in reducing bacterial presence and related inflammation in preliminary tests.
While this research does not definitively prove causation, it presents a compelling case for further investigation.
Commentary:
This study could represent a significant breakthrough in our understanding of Alzheimer’s and its potential triggers.
If gum disease bacteria play a role in brain degeneration, early prevention and treatment of oral infections could be a game-changer.
For decades, Alzheimer’s research has focused heavily on genetics and amyloid plaques, but this study suggests that infection-based theories deserve serious attention.
The possibility that a common and preventable bacterial infection could contribute to a devastating disease like Alzheimer’s reinforces the need for proactive health measures.
Good oral hygiene is already known to impact cardiovascular health, and now it may be linked to cognitive function as well.
Americans should take dental health more seriously—not just for a bright smile but potentially for a healthier brain.
If further studies confirm this connection, new treatment options could emerge.
The experimental drug COR388 showed promise in mice, but human trials will be the real test.
Given that there have been no major new Alzheimer’s treatments in over 15 years, exploring every possible avenue—including targeting bacterial infections—could lead to much-needed progress.
The Medical and Health Awareness (MAHA) initiative aims to highlight areas where Americans can take charge of their health.
This research aligns perfectly with that mission.
If preventing gum disease could lower the risk of Alzheimer’s, regular dental care could become an even more critical part of long-term health strategies.
The Bottom Line:
A growing body of evidence suggests that bacteria from gum disease could contribute to Alzheimer’s.
Researchers found P. gingivalis in the brains of Alzheimer’s patients, and early experiments show potential for treatments targeting this infection.
While more research is needed, maintaining good oral health could play a bigger role in preventing neurodegenerative diseases than previously thought.
Expect more studies to follow as scientists explore this promising new direction.
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